Résistance aux antibiotiques : de la santé humaine au changement climatique.

Marie-Cécile Ploy, Université de Limoges

Bacteria possess a variety of highly complex genetic elements that allow the horizontal transfer of resistance genes to members of different species or even different genera. Along with transposons and plasmids, integrons are important genetic substrates for resistance genes. Integrons capture and express resistance genes contained in so-called “gene cassettes”.

Our research concerns the study of the regulation of the integron integrase and resistance gene cassettes expression, particularly on the role of the SOS response and on transcriptional interference.

Furthermore, we develop clinical and translational research of the relevance of integrons as a marker of antibiotic resistance in different ecosystems (human, animal, environment)..

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